Here are some common nucleophiles used in organic chemistry SN1, SN2, E1, and E2 reactions, sorted by strength: VERY Good Nucleophiles: SH-, RS-, I- Good Nucleophiles: CN-, N3-, Br-, HO-, RO- Fair Nucleophiles: NH3, Cl-, F-, RCO2- Weak nucleophiles: H20, ROH VERY…
SN (nucleophilic substitution) vs. E (elimination) One of the most common questions in organic chemistry: “How do I know if a reaction will be SN1/SN2/E1/E2?” First question: what kind of halide are we dealing with? Methyl Halide: SN1 or SN2…
Overview of SN1 & SN2 Substitution Reactions The most basic substitution reaction: So what happened? C-O bond is made. C-Br bond is broken. Lewis Base (OH, in this case) donates electrons and forms a new bond to the central carbon.…